Panorama Test - genetic prenatal test

Prenatal test – Panorama

The Panorama test is an non-invasive, safe, prenatal screening.

The Panorama test enables quality assessment of the probability of common genetic flaws such as:

• Down syndrome
• Edwards syndrome
• Patau syndrome
• Turner syndrome
• Klinefelter syndrome
• Jacobs syndrome
• Triple X syndrome
• Triploid syndrome

The triploid syndrome is a chromosome abnormality connected with significant genetic flaws usually leading to foetal death. Child births in this condition are incredibly rare.

Apart from chromosome changes, the research assesses the risk rate of microdeletion gene syndromes. The Panorama test detects 5 of microdeletion syndromes:

• DiGeorge syndrome
• 1p36 deletion syndrome
• Angleman syndrome
• Prader-Willi Syndrome
• Cri du chat syndrome

Microdeletion is the absence of a miniscule part of a chromosome. Some microdeletions minimally alter the well-being of the child, however some cause brain damage and genetic flaws. Microdeletions occur at the same frequency, regardless of the mother’s age.

When to do the Test?

The test can be run after the end of the 9th week of pregnancy up until the labor.

Before doing the test, it is required to perform an ultrasonography to determine the number of foetuses and the week of pregnancy. That it is why we recommend running Panorama test after the first prenatal test (11-14 week of pregnancy).

In rare cases the test procedure might not be able to provide reliable result due to lack of enough information in the tested sample. In such case, it might be necessary t draw a second blood sample. Which can be done free of charge in the same blood draw point as the original draw. This issue is most frequent in patients with obesity

This test is meant for pregnant women, regardless the age, with the exception of:

• Multiple pregnancy,
• Previous death of one of two embryos
• Twin pregnancy via surrogate or egg donor
• Pregnancies post bone narrow transplant
• Blood transfusion less than 6 month prior
• Pregnancy earlier than the 10th week

Remember to fill out the required documents and learn about the process of performing Panorama test. If you’re having problem with filling out the required documents, contact your OB-Gyn for necessary support or read the sample referral (available under “Documents” tab). You can always contact our hotline to learn more about the test.

Why Panorama test + microdeletions panel ?

• Non-invasive test, safe for the faetus and the mother alike
• Provides information about the risk of particular genetic disorders in faetus
• The test can be run as soon as in the 9th week of pregnancy
• The test covers majority of the chromosome defects
• Allows for separation of freecell placenta DNA for the mother’s DNA
• Results available within 14 days
• The results are reliable due to the technology used in the process. Compared to other tests, PANORAMA offer a lower rate of false positive results. It also allows to detect more genetical disorders than Papp’s test

Scope:

The test evaluates the risk of chromosome anomalies and the widen range of microdeletions (DiGeorge Syndrome + 4 others)

This test is meant for pregnant women, regardless the age, with the exception of:

• Multiple pregnancy, over twin
• Previous death of one of two embryos
• Twin pregnancy via surrogate or egg donor

How to run the test?

1. Patient purchases the test online
2. Patient downloads and fills out the referral and consent declaration (available under “documents”). We highly recommend filling out the referral together if the OB-GYN managing pregnancy
3. Patient report to Blood Draw Point with all the above mentioned documents (recommended time is Monday-Thursday 8-11 am)
4. A trained nurse controls the documents and hands out an information leaflet about Panorama Test (also available under “Documents”
5. After a positive verification of the documents, blood sample is taken from patient’s arm
6. After up to 14 days patient receives telephone call informing her that the results are ready to be picked up at the reception desk.

You must have a valid ID on you when reporting for the blood draw!

We highly recommend discussing the results with trained OB-GYN Physician

Every patient must report to the blood draw point with all necessary documents! If you have problem filling them out, please see “Sample Referral” under “Documents” tab

Additional Information

The test is not a diagnostic examination, which means that it does not detect genetic diseases of the child, but does however estimate the risk rate of them occurring. The exam is based on a DNA analysis of the embryo, which is currently in the mother’s circulation system. The sample is taken to a laboratory where it is tested for genetic changes that could later impact the child’s health.

Panorama test is supplementary to regular screening tests performed in the first trimester of pregnancy, including USG, which should be run according to the current guidelines of The Polish Society Of Gynecologists and Obstetricians

You can consult advantages of Panorama Test after consultation with your OB-GYN Physician to make a conscious decision.

Panorama Test is a medical device. For your safety, use it according to the instructions or label. If in doubt, consult a specialist.